Endocrine Abstracts

Introduction: Extremely low levels of vitamin D usually include levels < 4 ng/ml, which is almost the same as undetectable. The risk groups for vitamin D deficiency have been identified, but do they allow such patients to be identified based solely on clinical presentation.Objective: To identify risk factors and their actual clinical determination in patients with 25(OH)D serum levels <4 ng/ml.Materials and methods: The stu...

Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and has a variable clinical presentation. Asymptomatic PHPT became the predominant form of the disease with increase of it’s incidence after the introduction of automated serum calcium measurement in North America and Europe. Data from Russia is lacking.Aim: To present the clinical profile of PHPT in Russia.Materials and methods: This retrospectiv...

Central diabetes insipidus (CDI) is a common complication after transsphenoidal treatment for tumors of the sellar region and may exhibit different patterns: transient, permanent or triphasic.The aim of our study was to determine the incidence and course of the CDI and to characterize the factors associated with resolution of this disease.The incidence of CDI was based on records of 318 patients who underwent transsphenoidal surger...

Objective: To analyze long-term treatment outcomes and to determine prognostic factors affecting the survival of patients with ECS. Matherials and methods: Retrospective, observational study on 147 patients (88 women, 59 men) with ECS diagnosed between 1990 and 2021. Various imaging studies were performed on all patients to find the source of ACTH producing neuroendocrine tumor (NET). Multivariable analysis was performed using a Cox proportional hazards ...

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

Introduction: ADH-deficiency (central diabetes insipidus, ADH-D) is a rare disease, and data on worldwide and country-specific prevalence rates are scarce. ADH-D registries could provide valuable information on epidemiology, etiological distribution, treatment requirements and potentially serve as a guide for management decisions in clinical practice.Objectives: To assess the epidemiological data on ADH-D in Russian Registry for Central Diabetes Insipidu...

Introduction: The treatment of choice for parathyroid carcinoma (PC) is a radical en bloc resection. Treatment options for patients with metastatic PC are limited especially if a complete tumor removal cannot be performed. We present four cases of PC patients with multiple metastasis and refractory hypercalcemia that eventually received a multikinase inhibitor with different response on therapy.Clinical cases: The first patient was a 27-year-old woman wi...

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome of abnormal phosphate metabolism caused by a small mesenchymal tumor that secrete fibroblast growth factor 23 (FGF23). A 29-year-old female has suffered from two low-traumatic hip fractures, multiple fractures at the pelvic and sacrum, and diffuse bone pain for more than 3 years. Her mobility was limited in the last year (used crutches) because she had severe muscle weakness. Laboratory examination at the time ...

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing syndrome and in 25–55% of cases is caused by mutations in ARMC5 gene. A 37 y.o. female was referred to our center with a diagnosis of ACTH-independent Cushing syndrome. Laboratory testing confirmed endogenous hypercortisolism (urinary free cortisol 5063.5 nmol/24 h (60–413), midnight salivary cortisol 56.6 nmol/l (0.5–9.4), midnight serum cortisol 1427 nmol/l (46–...